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The adrenal cortex is the outer region and also the largest part of the adrenal gland. It is divided into three separate zones: zona glomerulosa , zona fasciculata and zona reticularis . Each zone is responsible for producing specific hormones.
H & E staining of the adrenal cortex. The zona glomerulosa is the outermost layer, below the renal capsule (near the pointer) In response to increased potassium levels, renin or decreased blood flow to the kidneys, cells of the zona glomerulosa produce and secrete the mineralocorticoid aldosterone into the blood as part of the renin ...
The adrenal cortex is the outermost layer of the adrenal gland. Within the cortex are three layers, called "zones". When viewed under a microscope each layer has a distinct appearance, and each has a different function. [13] The adrenal cortex is devoted to production of hormones, namely aldosterone, cortisol, and androgens. [14]
The zona reticularis (sometimes, reticulate zone) is the innermost layer of the adrenal cortex, lying deep to the zona fasciculata and superficial to the adrenal medulla. The cells are arranged cords that project in different directions giving a net-like appearance (L. reticulum - net).
Steroid-producing adrenal tumours and hyperplasia of the zona fasciculata result in excess cortisol production and are the cause for adrenal Cushing's syndrome. [1] The genetic disorder McCune–Albright syndrome can also present as Cushing's syndrome in affected patients. Adrenal gland (zona fasciculata layer).
Schematic of the HPA axis (CRH, corticotropin-releasing hormone; ACTH, adrenocorticotropic hormone) Hypothalamus, pituitary gland, and adrenal cortex The hypothalamic–pituitary–adrenal axis (HPA axis or HTPA axis) is a complex set of direct influences and feedback interactions among three components: the hypothalamus (a part of the brain located below the thalamus), the pituitary gland (a ...
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At the end of the eighth week, the adrenal glands have been encapsulated and have formed a distinct organ above the developing kidneys. [4] At birth, the adrenal glands weigh approximately eight to nine grams (twice that of the adult adrenal glands) and are 0.5% of the total body weight. At 25 weeks, the adult adrenal cortex zone develops and ...