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Platelet-rich plasma (PRP) is an emerging technique in tissue regeneration, increasingly used to enhance healing in dental and oral surgery, particularly for aging patients. PRP is derived from the patient's blood through centrifugation, concentrating growth factors that are crucial for wound healing and tissue repair.
Platelet-rich fibrin (PRF) or leukocyte- and platelet-rich fibrin (L-PRF) is a derivative of PRP where autologous platelets and leukocytes are present in a complex fibrin matrix [1] [2] to accelerate the healing of soft and hard tissue [3] and is used as a tissue-engineering scaffold in oral and maxillofacial surgeries. PRF falls under FDA ...
Rehabilitation following any articular cartilage repair procedure is paramount for the success of any articular cartilage resurfacing technique. The rehabilitation is often long and demanding. The main reason is that it takes a long time for the cartilage cells to adapt and mature into repair tissue. Cartilage is a slow adapting substance.
Articular cartilage does not usually regenerate (the process of repair by formation of the same type of tissue) after injury or disease leading to loss of tissue and formation of a defect. This fact was first described by William Hunter in 1743. [1] Several surgical techniques have been developed in the effort to repair articular cartilage defects.
Because of their multi-potent capabilities, mesenchymal stem cell (MSC) lineages have been used successfully in animal models to regenerate articular cartilage and in human models to regenerate bone. [ 4 ] [ 5 ] [ 6 ] Recent research demonstrates that articular cartilage may be able to be repaired via the percutaneous introduction of ...
Therefore, to regenerate hollow organs and tissues with a long diffusion distance, the tissue had to be regenerated inside the lab, via the use of a 3D printer. [2] Various tissues that have been regenerated by in vitro 3D printing include: The first organ ever induced and made in the lab was the bladder, which was created in 1999. [15]
Articular cartilage is a connective tissue overlying the ends of bones that provides smooth joint surfaces. Healthy cartilage is essential to the proper functioning of joints within the body. Cartilage is composed of cells embedded in an extracellular matrix of collagen fibers and proteoglycans.
In the case of wounded fetal tissue, however, wounded tissue is replaced with normal tissue through the activity of stem cells. [69] A possible method for tissue regeneration in adults is to place adult stem cell "seeds" inside a tissue bed "soil" in a wound bed and allow the stem cells to stimulate differentiation in the tissue bed cells.