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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [ 2 ] [ 3 ] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity.
Research into genetic factors and potential treatments is still underway, but Scherer said the current best approach to medical treatment of obesity is GLP-1 medications.
Numerous studies aimed to provide insight into genetic, economic, and/or environmental causes of obesity. According to the "thrifty gene hypothesis, [18] a genetic theory explaining rising obesity rates, certain individuals are genetically predisposed to metabolize food more efficiently than others as a result of human evolution. In times of ...
Scientists from the University of Exeter Medical School have found that people missing a specific blood group due to a genetic variant may be genetically predisposed to having obesity or overweight.
FTO has been demonstrated to efficiently demethylate the related modified ribonucleotide, N6,2'-O-dimethyladenosine, and to an equal or lesser extent, m 6 A, in vitro . [5] [15] FTO knockdown with siRNA led to increased amounts of m 6 A in polyA-RNA, whereas overexpression of FTO resulted in decreased amounts of m 6 A in human cells. [10]
Monogenic obesity is excess weight caused by a mutation in a single gene, as opposed to syndromic obesity not tied to a single gene variation and most obesity, which is caused by multiple genetic and environmental risk factors. Monogenetic obesity mostly affects the hypothalamus and leptin–melanocortin system (see hypothalamic obesity ...
Some people’s genetics predispose them to obesity. But nature is not destiny. Here are five tips for losing weight.
Individuals who, due to genetic mutation, are unable to produce functional leptin or who produce leptin but are insensitive to it are prone to develop obesity. [4] This has been confirmed by experimental "knockdown" of leptin receptors in the lateral hypothalamus in rats, which caused the rats to consume more calories and increase in body ...