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MiR-1 may have a tumour-suppressive effect in bladder cancer by regulation of LIM and SH3 protein 1 . [17] There is evidence for the role of miR-1-2 as a modulator in acute myeloid leukemia via its transcription by the zinc-finger transcription factor, EVI1, ectopic virus expression site 1. ChIP assays have shown that EVI1 binds strongly to the ...
[1] One mir-2 microRNA in Drosophila, dme-miR-2a-2 , is two nucleotides offset with respect to the canonical products of other mir-2 precursors. [5] This is likely to affect the function of that particular microRNA. This functional shift is associated to a change in the genomic distribution of mir-2 sequences in Drosophila.
The mir-BHRF1-2 microRNA precursor found in human herpesvirus 4 (Epstein–Barr virus), cercopithicine herpesvirus 15 and herpesvirus papio. In Epstein-Barr virus, mir-BHRF1-2 is found in the 3' UTR of the BHRF1 (Bam HI fragment H rightward open reading frame 1) gene, which is known to encode a distant Bcl-2 homolog.
For example, the pre-miRNAs hsa-mir-194-1 and hsa-mir-194-2 lead to an identical mature miRNA (hsa-miR-194) but are from genes located in different genome regions. Species of origin is designated with a three-letter prefix, e.g., hsa-miR-124 is a human (Homo sapiens) miRNA and oar-miR-124 is a sheep (Ovis aries) miRNA.
miR-134 is a family of microRNA precursors found in mammals, including humans. [1] MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. [2] The excised region or, mature product, of the miR-134 precursor is the microRNA mir-134.
That is, until Ruvkun discovered another microRNA in 2000: this time one that also appeared in mice, other animals and, importantly, humans. The future of microRNA
The miR-15 microRNA precursor family is made up of small non-coding RNA genes that regulate gene expression. The family includes the related mir-15a and mir-15b sequences, as well as miR-16-1, miR-16-2, miR-195 and miR-497. These six highly conserved miRNAs are clustered on three separate chromosomes. [1]
The mature products are thought to have regulatory roles through complementarity to mRNA. miR-24 is conserved in various species, and is clustered with miR-23 and miR-27, on human chromosome 9 and 19. [1] Recently, miR-24 has been shown to suppress expression of two crucial cell cycle control genes, E2F2 and Myc in hematopoietic differentiation ...