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DOTA-TATE can be reacted with the radionuclides gallium-68 (T 1/2 = 68 min), lutetium-177 (T 1/2 = 6.65 d) and copper-64 (T 1/2 = 12.7 h) to form radiopharmaceuticals for positron emission tomography (PET) imaging or radionuclide therapy. 177 Lu DOTA-TATE therapy is a form of peptide receptor radionuclide therapy (PRRT) which targets ...
As well as diagnosis and staging of NETs, 68 Ga DOTA conjugated peptide imaging may be used for planning and dosimetry in preparation for lutetium-177 or yttrium-90 DOTA therapy. [35] [36] In June 2016, Netspot (kit for the preparation of gallium Ga-68 dotatate injection) was approved for medical use in the United States. [37] [38]
Gallium (68 Ga) gozetotide or Gallium (68 Ga) PSMA-11 sold under the brand name Illuccix among others, is a radiopharmaceutical made of 68 Ga conjugated to prostate-specific membrane antigen (PSMA) targeting ligand, Glu-Urea-Lys(Ahx)-HBED-CC, used for imaging prostate cancer by positron emission tomography (PET). [11]
Gallium-68 is only used as a positron emitting tag for a ligand which binds to certain tissues, such as DOTATOC, which is a somatostatin analogue useful for imaging neuroendocrine tumors. Gallium-68 DOTA scans are increasingly replacing octreotide scans (a type of indium-111 scan using octreotide as a somatostatin receptor ligand).
The mobile phase is a solvent able to elute (wash out) gallium-68 (III) (68 Ga 3+) after it has been produced by electron capture decay from the immobilized (absorbed) germanium-68. Currently, such 68 Ga (III) is easily eluted with a few mL of 0.05 M, 0.1 M or 1.0 M hydrochloric acid from generators using metal-free tin dioxide [ 3 ] or ...
Copper (64 Cu) oxodotreotide or Copper Cu 64 dotatate, sold under the brand name Detectnet, is a radioactive diagnostic agent indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adults. [2] Common side effects include nausea, vomiting and flushing. [3]
May 2003 - The New Jersey Motor Vehicle Commission is formed, replacing the DMV notorious for poor customer service. January 2004 - The MVC issues the state's first, security-enhanced Digital Driver License (DDL). January 2004 - The MVC reinstitutes Saturday hours of service. August 2004 - The MVC begins On-Board Diagnostics (OBD) vehicle testing.
Iodine-131 (131 I) is the most common RNT worldwide and uses the simple compound sodium iodide with a radioactive isotope of iodine.The patient (human or animal) may ingest an oral solid or liquid amount or receive an intravenous injection of a solution of the compound.