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Overview of signal transduction pathways involved in apoptosis. Cell death is the event of a biological cell ceasing to carry out its functions. This may be the result of the natural process of old cells dying and being replaced by new ones, as in programmed cell death, or may result from factors such as diseases, localized injury, or the death of the organism of which the cells are part.
Necrosis (from Ancient Greek νέκρωσις (nékrōsis) 'death') is a form of cell injury which results in the premature death of cells in living tissue by autolysis. [1] The term "necrosis" came about in the mid-19th century and is commonly attributed to German pathologist Rudolf Virchow , who is often regarded as one of the founders of ...
A fresh pig carcass. At this stage the remains are usually intact and free of insects. The corpse progresses through algor mortis (a reduction in body temperature until ambient temperature is reached), rigor mortis (the temporary stiffening of the limbs due to chemical changes in the muscles), and livor mortis (pooling of the blood on the side of the body that is closest to the ground).
The definition of legal death, and its formal documentation in a death certificate, vary according to the jurisdiction. The certification applies to somatic death , corresponding to death of the person, which has varying definitions but most commonly describes a lack of vital signs and brain function. [ 9 ]
During embryogenesis, for a number of cell cleavages (the specific number depends on the type of organism) all the cells of an embryo will be morphologically and developmentally equivalent. This means, each cell has the same development potential and all cells are essentially interchangeable, thus establishing an equivalence group. The ...
A set of recommendations for describing the terminology of cell death was proposed by the Nomenclature Committee on Cell Death (NCCD) in 2009, because misusing words and concepts may slow down progress in the area of cell death research. [1] The classic definition of death defines it as a state characterized by the cessation of signs of life.
In biology, a biological life cycle (or just life cycle when the biological context is clear) is a series of stages of the life of an organism, that begins as a zygote, often in an egg, and concludes as an adult that reproduces, producing an offspring in the form of a new zygote which then itself goes through the same series of stages, the ...
For many years, neither "apoptosis" nor "programmed cell death" was a highly cited term. Two discoveries brought cell death from obscurity to a major field of research: identification of the first component of the cell death control and effector mechanisms, and linkage of abnormalities in cell death to human disease, in particular cancer.