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Sirtuin 4, also known as SIRT4, is a mitochondrial protein which in humans is encoded by the SIRT4 gene. [5] [6] SIRT4 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein. SIRT4 exhibits NAD+-dependent deacetylase activity.
any string of characters drawn from the alphabet enclosed in square brackets matches any one of the corresponding amino acids; e.g. [abc] matches any of the amino acids represented by a or b or c. The fundamental idea behind all these notations is the matching principle, which assigns a meaning to a sequence of elements of the pattern notation:
A string is defined as a contiguous sequence of code units terminated by the first zero code unit (often called the NUL code unit). [1] This means a string cannot contain the zero code unit, as the first one seen marks the end of the string. The length of a string is the number of code units before the zero code unit. [1]
A sequence begins with a greater-than character (">") followed by a description of the sequence (all in a single line). The lines immediately following the description line are the sequence representation, with one letter per amino acid or nucleic acid, and are typically no more than 80 characters in length. For example:
procedure k-mers(string seq, integer k) is L ← length(seq) arr ← new array of L − k + 1 empty strings // iterate over the number of k-mers in seq, // storing the nth k-mer in the output array for n ← 0 to L − k + 1 exclusive do arr[n] ← subsequence of seq from letter n inclusive to letter n + k exclusive return arr
Protein primary structure is the linear sequence of amino acids in a peptide or protein. [1] By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end. Protein biosynthesis is most commonly performed by ribosomes in cells. Peptides can also be synthesized in the ...
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The absence of substitutions, or the presence of only very conservative substitutions (that is, the substitution of amino acids whose side chains have similar biochemical properties) in a particular region of the sequence, suggest [3] that this region has structural or functional importance.