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The efficacy of solifenacin to treat neurogenic detrusor overactivity (NDO) was established in two clinical trials with a total of 95 pediatric NDO participants, ages two to 17 years old. [2] The studies were designed to measure (as a primary efficacy endpoint) the maximum amount of urine the bladder could hold after 24 weeks of treatment. [2]
The CDC recommends three flu vaccines for people 65 and older: the Fluzone High-Dose inactivated flu ... is most effective in the first year and wanes over 10 years. ... and pregnant women.
If there is no guidance then pick the mid point between the dose range extremes. The DDD of a drug is reviewed after three years. Ad hoc requests for change may be made but are discouraged and generally not permitted unless the main indication for the drug has changed or the average dose used has changed by more than 50%. [3]
In over-the-counter medicines, both dose and dosage is usually based on age. Typically, different doses are recommended for children 6 years and under, for children aged 6 to 12 years, and for persons 12 years and older, but outside of those ranges the guidance is slim. [ 2 ]
Adults aged 65 years and older are disproportionately impacted by COVID-19, with more than half of COVID-19 hospitalizations during October 2023 to December 2023 occurring in this age group, the ...
The CDC has recommended seniors receive a second dose of the 2023-2024 COVID-19 vaccine, depending on when their last vaccine or infection took place.
For many drugs, severe toxicities in humans occur at sublethal doses, which limit their maximum dose. A higher safety-based therapeutic index is preferable instead of a lower one; an individual would have to take a much higher dose of a drug to reach the lethal threshold than the dose taken to induce the therapeutic effect of the drug.
For the drugs administered by oral and dermal route, the units of threshold dose are mg/kg body-weight/day (dose of the drug in mg per body weight in kg per day) or ppm (parts per million), while the threshold dose of drugs by inhalation delivery has the unit of mg/L 6h/day (amount of drug in mg in 1L of air, for 6 hours per day).