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Puberty blockers (also called puberty inhibitors or hormone blockers) are medicines used to postpone puberty in children. The most commonly used puberty blockers are gonadotropin-releasing hormone (GnRH) agonists, which suppress the natural production of sex hormones, such as androgens (e.g. testosterone) and estrogens (e.g. estradiol).
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GnRH antagonists could be used as puberty blockers in transgender youth and to suppress sex hormone levels in transgender adolescents and adults. [12] [13] [14] [15]
“Puberty blockers are sort of like a man-made hormone analogue, and basically what they do is fool the brain into not sending messages to the ovaries and testes to secrete hormones,” said Dr ...
The Cass Review into children’s gender services has prompted a change in approach.
Puberty blockers are used to delay the onset of puberty by blocking the body from making sex hormones such as testosterone and estrogen. The hormonal suppressants do not reverse any changes that ...
Additionally, puberty blockers can be prescribed for children with severe forms of idiopathic short stature, allowing for more time for growth before the closure of growth plates. [47] In the USA, since 1993, the US Food and Drug Administration (FDA) has supported the use of puberty blockers to treat precocious puberty. [48]
Puberty blockers are licensed to treat early-onset puberty in children – but over the past decade, there has been a significant increase in demand for them to be given to children and young ...