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In plants, nitric oxide can be produced by any of four routes: (i) L-arginine-dependent nitric oxide synthase, [54] [55] [56] (although the existence of animal NOS homologs in plants is debated), [57] (ii) plasma membrane-bound nitrate reductase, (iii) mitochondrial electron transport chain, or (iv) non-enzymatic reactions.
L-arginine is recognized as safe (GRAS-status) at intakes of up to 20 grams per day. [51] L-arginine is found in many foods, such as fish, poultry, and dairy products, and is used as a dietary supplement. [52] It may interact with various prescription drugs and herbal supplements. [52]
Arginine alpha-ketoglutarate (AAKG) is a salt of the amino acid arginine and alpha-ketoglutaric acid. It is marketed as a bodybuilding supplement. [1] Peer-reviewed studies have found no increase in muscle protein synthesis or improvement in muscle strength from use of AAKG as a dietary supplement. [1] [2] [3]
Homocitrulline has been suggested as a confounding antigen for rheumatoid arthritis antibodies targeting citrullinated proteins/peptides. [1] Antibodies binding to homocitrulline-containing sequences have been found in rheumatoid arthritis patients' sera [2] [3] More recently, it has been shown that homocitrulline-containing proteins are present in rheumatoid arthritis (RA) joints. [4]
The first section of this page concludes with the line: "In general, most people do not need to take arginine supplements because the body usually produces enough.[4]" I am not sure if I follow this logic here, as, in general, most people do not need to supplement their intake of any amino acid.
When PAD converts arginine to citrulline on a histone, it blocks further methylation of the histone, inhibiting transcription. [ 8 ] [ 9 ] The main isotype for this is PAD4, which deiminates arginines and/or monomethylated arginines on histones 3 and 4, turning off the effects of arginine methylation.
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