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Thyroid disease is a medical condition that affects the structure and/or function of the thyroid gland. The thyroid gland is located at the front of the neck and produces thyroid hormones [ 1 ] that travel through the blood to help regulate many other organs, meaning that it is an endocrine organ .
The Endocrine Society recommends screening in pregnant women who are considered high-risk for thyroid autoimmune disease. [130] Universal screening for thyroid diseases during pregnancy is controversial, however, one study "supports the potential benefit of universal screening". [131]
An abnormal basal metabolic rate is not necessarily indicative of disease; a number of physiological factors can alter the BMR by influencing cellular metabolic activity. [1] For instance, males are more likely than females to have a high BMR, and in women, the BMR may rise to abnormal levels during pregnancy or lactation. [ 2 ]
Hypothyroidism is more common in women than in men. [3] People over the age of 60 are more commonly affected. [3] Dogs are also known to develop hypothyroidism, as are cats and horses, albeit more rarely. [13] The word hypothyroidism is from Greek hypo-'reduced', thyreos 'shield', and eidos 'form', where the two latter parts refer to the ...
Regardless of the inconsistent findings, a 2007 study by Andersen et al. states that the distinction between sub-clinical and overt thyroid disease is in any case somewhat arbitrary. [55] Sub-clinical hyperthyroidism has been reported in 63% of euthyroid Graves' disease, [56] but only in 4% of cases where Graves' disease was in remission. [57]
An association between thyroid disease and myasthenia gravis has been recognized. Thyroid disease, in this condition, is autoimmune in nature and approximately 5% of people with myasthenia gravis also have hyperthyroidism. Myasthenia gravis rarely improves after thyroid treatment and the relationship between the two entities is becoming better ...
Thyroglobulin antibodies are specific for thyroglobulin, a 660 kDa matrix protein involved in the process of thyroid hormone production. They are found in 70% of Hashimoto's thyroiditis, 60% of idiopathic hypothyroidism, 30% of Graves' disease, a small proportion of thyroid carcinoma and 3% of normal individuals.
Thyroid cancer is three times more common in women than in men. [60] The overall relative 5-year survival rate for thyroid cancer is 85% for females and 74% for males. [61] The identification of some molecular or DNA abnormalities has led to the development of therapies that target these molecular defects.
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