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Chiral analysis refers to the quantification of component enantiomers of racemic drug substances or pharmaceutical compounds. Other synonyms commonly used include enantiomer analysis, enantiomeric analysis, and enantioselective analysis. Chiral analysis includes all analytical procedures focused on the characterization of the properties of ...
A chiral switch is a chiral drug that has already approved as racemate but has been re-developed as a single enantiomer. [ 1 ][ 2 ] The term chiral switching was introduced by Agranat and Caner in 1999 [ 3 ] to describe the development of single enantiomers from racemate drugs. For example, levofloxacin is a chiral switch of racemic ofloxacin.
Enantiopure drug. An enantiopure drug is a pharmaceutical that is available in one specific enantiomeric form. Most biological molecules (proteins, sugars, etc.) are present in only one of many chiral forms, so different enantiomers of a chiral drug molecule bind differently (or not at all) to target receptors.
Itraconazole. Itraconazole, sometimes abbreviated ITZ, is an antifungal medication used to treat a number of fungal infections. [7] This includes aspergillosis, blastomycosis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis. [7] It may be given by mouth or intravenously.
Esomeprazole, sold under the brand name Nexium [or Neksium] among others, [2] is a medication which reduces stomach acid. [11] It is used to treat gastroesophageal reflux disease, peptic ulcer disease, and Zollinger–Ellison syndrome. [11][12] Its effectiveness is similar to that of other proton pump inhibitors (PPIs). [13]
Chirality(/kaɪˈrælɪti/) is a property of asymmetryimportant in several branches of science. The word chiralityis derived from the Greekχείρ(kheir), "hand", a familiar chiral object. An object or a system is chiralif it is distinguishable from its mirror image; that is, it cannot be superposed(not to be confused with superimposed) onto it.
Chiral media. Chirality with hands and two enantiomers of a generic amino acid. The direction of current flow and induced magnetic flux follow a "handness" relationship. The term chiral / ˈkaɪrəl / describes an object, especially a molecule, which has or produces a non-superposable mirror image of itself. In chemistry, such a molecule is ...
In stereochemistry, a chiral auxiliary is a stereogenic group or unit that is temporarily incorporated into an organic compound in order to control the stereochemical outcome of the synthesis. [1][2] The chirality present in the auxiliary can bias the stereoselectivity of one or more subsequent reactions. The auxiliary can then be typically ...