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Botulinum toxin, or botulinum neurotoxin (commonly called botox), is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. [24] It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction, thus causing flaccid paralysis. [25]
From or to a drug trade name: This is a redirect from (or to) the trade name of a drug to (or from) the international nonproprietary name (INN).
Medicis Pharmaceutical is a medical cosmetics company based in Bridgewater, New Jersey.It is a subsidiary of Valeant Pharmaceuticals, which acquired the company in 2012. [1] [2] Medicis is known for products such as Solodyn and Ziana for treating acne, and for Restylane and Dysport for treating facial wrinkles.
Botox or Dysport injections have the advantage of ready availability (the same form is used for cosmetic surgery) and the effects are not permanent. There is a risk of temporary paralysis of the muscles being injected or the leaking of the toxin into adjacent muscle groups, causing weakness or paralysis in them.
Since the advent of the hugely popular wrinkle remover, Botox (Dysport in the United Kingdom and Europe) many consumers have eschewed the invasive surgery altogether, opting for Botox injections every four to six months to get the same results. Botox is also used after some forehead lift procedures to increase the effects of the surgeries.
Wikipedia [c] is a free-content online encyclopedia written and maintained by a community of volunteers, known as Wikipedians, through open collaboration and the wiki software MediaWiki.
The origins of Galderma date back to 1961 and the founding of the Owen dermatology company in Dallas, Texas, USA by M. Owen. [4]. In 1979, Hans Schaefer founded the International Center for Dermatological Research (CIRD) in Sophia Antipolis, with the support of the CEO of L'Oréal, François Dalle, who wanted to diversify his cosmetic research into the drug sector.
The 5-chloro-2,1,3-benzothiadiazol-4-amine intermediate was a known compound, produced in three steps from 4-chlorophenylenediamine as shown. [18] Treatment with two equivalents of thionyl chloride in pyridine formed the heterocycle , which was nitrated with sodium nitrate in sulfuric acid and reduced using iron and acetic acid.
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