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Acetazolamide is a first generation carbonic anhydrase inhibitor and it decreases the ocular fluid and osmolality in the eye to decrease intraocular pressure. [5] [6] Common side effects include numbness, ringing in the ears, loss of appetite, vomiting, and sleepiness. [2]
Acetazolamide can be taken before symptoms appear as a preventive measure at a dose of 125 mg twice daily. The Everest Base Camp Medical Centre cautions against its routine use as a substitute for a reasonable ascent schedule, except where rapid ascent is forced by flying into high altitude locations or due to terrain considerations. [21]
High-altitude cerebral edema (HACE) is a medical condition in which the brain swells with fluid because of the physiological effects of traveling to a high altitude. It generally appears in patients who have acute mountain sickness and involves disorientation, lethargy, and nausea among other symptoms.
The effects of high altitude on humans are mostly the consequences of reduced partial pressure of oxygen in the atmosphere. The medical problems that are direct consequence of high altitude are caused by the low inspired partial pressure of oxygen, which is caused by the reduced atmospheric pressure, and the constant gas fraction of oxygen in ...
Re-entry HAPE is also an entity that has been described in persons who normally live at high altitude but who develop pulmonary edema after returning from a stay at low altitude. [3] If HAPE is not treated, there is a 50% risk of mortality. [4] Symptoms include crackling sounds when breathing, dyspnea (at rest), and cyanosis. [4]
At very high altitude, from 3,500 to 5,500 metres (11,500 to 18,000 ft) arterial oxygen saturation falls below 90% and arterial P O 2 is reduced to the extent that extreme hypoxemia may occur during exercise and sleep, and if high altitude pulmonary edema occurs. In this range severe altitude illness is common.
In 2010, for the first time, the genes responsible for the unique adaptive traits were identified following genome sequencing of 50 Tibetans and 40 Han Chinese from Beijing. Initially, the strongest signal of natural selection was a transcription factor involved in response to hypoxia, called endothelial Per-Arnt-Sim (PAS) domain protein 1 ...
Hypobaric chamber at the Biopol'H, in Catalonia (), used with patients and athletes who need treatment or training with reduced atmospheric pressure. A hypobaric chamber, or altitude chamber, is a chamber used during aerospace or high terrestrial altitude research or training to simulate the effects of high altitude on the human body, especially hypoxia (low oxygen) and hypobaria (low ambient ...
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