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Trifluoromethanol is a synthetic organic compound with the formula CHF 3 O. [1] It is also referred to as perfluoromethanol or trifluoromethyl alcohol.
Trifluoromethyl group covalently bonded to an R group. The trifluoromethyl group is a functional group that has the formula-CF 3.The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom.
Preparation of the trifluoromethyltrimethylsilane was reported by Ingo Ruppert in 1984. [11] In 1989, Prakash and Olah first reported activation of TMSCF 3 by fluoride to perform nucleophilic trifluoromethylation of carbonyl compounds. [12]
Fluoroform is weakly acidic with a pK a = 25–28 and quite inert. Attempted deprotonation results in defluorination to generate F − and difluorocarbene (CF 2).Some organocopper and organocadmium compounds have been developed as trifluoromethylation reagents.
Most primary and secondary perfluoroalcohols are unstable, for example trifluoromethanol eliminates hydrogen fluoride, forming carbonyl fluoride. [2] This reaction is reversible. [3] CF 3 OH → COF 2 + HF. Stable perfluorinated alcohols include nonafluoro-tert-butyl alcohol ((CF 3) 3 COH) and pentafluorophenol (C 6 F 5 OH).
Common trihalomethanes (ordered by molecular weight) ; Molecular formula IUPAC name CAS registry number Common name Other names Molecule CHF 3: trifluoromethane 75-46-7 ...
Trifluoroethanol is produced industrially by hydrogenation or the hydride reduction of derivatives of trifluoroacetic acid, such as the esters or acyl chloride. [1]TFE can also be prepared by hydrogenolysis of compounds of generic formula CF 3 −CHOH−OR (where R is hydrogen or an alkyl group containing from one to eight carbon atoms), in the presence of a palladium containing catalyst ...
4-Trifluoromethylbenzaldehyde is the organofluorine compound with the formula CF 3 C 6 H 4 CHO.Two other isomers are also known: 2-trifluoromethylbenzaldehyde and 3-trifluoromethylbenzaldehyde.