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The first to investigate trifluoromethyl groups in relationship to biological activity was F. Lehmann in 1927. [5] An early review appeared in 1958. [6] An early synthetic method was developed by Frédéric Swarts in 1892, [7] based on antimony fluoride.
Colorless liquid Density: 1.5±0.1 g/cm 3: ... trifluoromethanol can be prepared from trifluoromethyl hypochlorite and ... in an aqueous solution displaced by an acid ...
Trifluoromethyltrimethylsilane (known as Ruppert-Prakash reagent, TMSCF 3) is an organosilicon compound with the formula CF 3 Si(CH 3) 3.It is a colorless liquid. The compound is a reagent used in organic chemistry for the introduction of the trifluoromethyl group.
For small-scale laboratory preparations, trifluorotoluene is synthesized by coupling an aromatic halide and trifluoromethyl iodide in the presence of a copper catalyst: [2] PhX + CF 3 I → PhCF 3 (where X = I, Br) Industrial production is done by reacting benzotrichloride with hydrogen fluoride in a pressurized reactor. [3] PhCCl 3 + 3 HF → ...
Trifluoromethyl group covalently bonded to an R group. The trifluoromethyl group is a functional group that has the formula-CF 3. The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H– CF 3, 1,1,1-trifluoroethane H ...
The typical impurity in triflic anhydride is triflic acid, which is also a colorless liquid. Samples of triflic anhydride can be assayed by 19 F NMR spectroscopy: −72.6 ppm [8] vs. −77.3 for TfOH (std CFCl 3).
Trifluoroiodomethane, also referred to as trifluoromethyl iodide is a halomethane with the formula CF 3 I. It is an experimental alternative to Halon 1301 (CBrF 3 ) in unoccupied areas. [ 1 ] It would be used as a gaseous fire suppression flooding agent for in-flight aircraft and electronic equipment fires.
Two other isomers are also known: 2-trifluoromethylbenzaldehyde and 3-trifluoromethylbenzaldehyde. These compounds are derivatives of benzaldehyde with trifluoromethyl substituents. The CF 3 group enhances the electrophilicity of the formyl group and provides a label for analysis by fluorine-19 nuclear magnetic resonance spectroscopy.