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Dapoxetine is absorbed and distributed rapidly in the body. Greater than 99% of dapoxetine is bound to the plasma protein. The mean steady-state volume is 162 L. Its initial half-life is 1.31 hours (30 mg dose) and 1.42 hours (60 mg dose), and its terminal half life is 18.7 hours (30 mg dose) and 21.9 hours (60 mg dose). [27] Metabolism
Dapoxetine in particular takes advantage of the side effect of delayed orgasm and is approved specifically as a medication for the treatment of premature ejaculation rather than as an antidepressant. The side effects on sexual functioning can impact mental health and quality of life. [36]
Reports of PSSD have occurred with almost every SSRI (dapoxetine is an exception). [64] In 2019, the Pharmacovigilance Risk Assessment Committee of the European Medicines Agency (EMA) recommended that packaging leaflets of selected SSRIs and SNRIs should be amended to include information regarding a possible risk of persistent sexual ...
The U.S. Food and Drug Administration has recalled thousands of bottles of the antidepressant Duloxetine for potentially cancer-causing chemicals above the acceptable limit set by the FDA, per the ...
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ATC code G04 Urologicals is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
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