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Vitamin D toxicity, or hypervitaminosis D, is the toxic state of an excess of vitamin D.The normal range for blood concentration of 25-hydroxyvitamin D in adults is 20 to 50 nanograms per milliliter (ng/mL).
The UK National Health Service (NHS) recommends that people at risk of vitamin D deficiency, breast-fed babies, formula-fed babies taking less than 500 ml/day, and children aged 6 months to 4 years, should take daily vitamin D supplements throughout the year to ensure sufficient intake. [57]
Metabolites: Several vitamin D metabolites are found in cerebral spinal fluid and have the ability to cross the blood brain barrier. This is similar to many of the previously known neurosteroids. These vitamin D metabolites include 25-hydroxyvitamin D 3, 1,25-dihydroxyvitamin D 3, and 24,25-dihydroxyvitamin D 3. [1]
Calcifediol binds in the blood to vitamin D-binding protein (also known as gc-globulin) and is the main circulating vitamin D metabolite. [4] [5] Calcifediol has an elimination half-life of around 15 to 30 days. [4] [9] Calcifediol is further hydroxylated at the 1-alpha-position in the kidneys to form 1,25-(OH) 2 D 3, calcitriol.
The liver is required to transform vitamin D into 25-hydroxyvitamin D. This is an inactive metabolite of vitamin D but is a necessary precursor (building block) to create the active form of vitamin D. [1] The kidneys are responsible for converting 25-hydroxyvitamin D to 1,25-hydroxyvitamin D. This is the active form of vitamin D in the body.
Trout is an excellent source of vitamin D, with a 3-ounce serving providing 645 IU—more than 100% of the daily recommended intake for most adults. This makes it one of the richest natural ...
Vitamin D is a dietary requirement for cats as they lack the ability to efficiently synthesize vitamin D3 using sunlight. This fat-soluble vitamin is required in cats for bone formation through the promotion of calcium retention, along with nerve and muscle control through absorption of calcium and phosphorus.
The main metabolite excreted in the urine is 11-Nor-9-carboxy-THC, also known as THC-COOH. Most cannabis drug tests yield a positive result when the concentration of THC-COOH in urine exceeds 50 ng/mL. [10] Urine testing is an immunoassay based test on the principle of competitive binding. Drugs which may be present in the urine specimen ...
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