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Antifolates act primarily as inhibitors of both RNA and DNA, and are often grouped with nucleic acid inhibitors in textbooks. However, they also act indirectly as protein synthesis inhibitors (because tetrahydrofolate is also involved in the synthesis of amino acids serine and methionine), so they are sometimes considered as their own category, antimetabolites. [6]
A protein synthesis inhibitor is a compound that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to the generation of new proteins. [ 1 ] A ribosome is a biological machine that utilizes protein dynamics on nanoscales to translate RNA into proteins
Protein synthesis inhibitor antibiotics (6 C, 7 P) R. Ribosome-inactivating proteins (13 P) Pages in category "Protein synthesis inhibitors" The following 9 pages are ...
There are three known classes of NS5B inhibitors: non-nucleoside analogue inhibitors, nucleoside/nucleotide analogue inhibitors, and pyrophosphate analogues. [2] The classes differ in their structure and where they bind to the NS5B protein: at allosteric binding sites, the enzyme active site, or the pyrophosphate binding site, respectively. [13]
1555 13088 Ensembl ENSG00000197408 ENSMUSG00000030483 UniProt P20813 P12791 RefSeq (mRNA) NM_000767 NM_009999 RefSeq (protein) NP_000758 n/a Location (UCSC) Chr 19: 40.99 – 41.02 Mb Chr 7: 25.6 – 25.63 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6 gene. CYP2B6 is a member of the cytochrome P450 group of ...
Inhibitors of PDE can prolong or enhance the effects of physiological processes mediated by cAMP or cGMP by inhibition of their degradation by PDE. [13] Sildenafil (Viagra) is an inhibitor of cGMP-specific phosphodiesterase type 5, which enhances the vasodilatory effects of cGMP in the corpus cavernosum and is used to treat erectile dysfunction.
Mycophenolate mofetil is an immunosuppressant drug used to prevent rejection in organ transplantation; it inhibits purine synthesis by blocking inosine monophosphate dehydrogenase (IMPDH). [5] Methotrexate also indirectly inhibits purine synthesis by blocking the metabolism of folic acid (it is an inhibitor of the dihydrofolate reductase).
The antiviral drug aciclovir (bottom), a nucleoside analogue that functions by mimicking guanosine (top) Nucleoside analogues are structural analogues of a nucleoside, which normally contain a nucleobase and a sugar. Nucleotide analogues are analogues of a nucleotide, which normally has one to three phosphates linked to a nucleoside.
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