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In United States Pharmacopeia (USP) General Chapter <711> Dissolution, there are four dissolution apparatuses standardized and specified. [6] They are: USP Dissolution Apparatus 1 – Basket (37 °C ± 0.5 °C ) USP Dissolution Apparatus 2 – Paddle (37 °C ± 0.5 °C) USP Dissolution Apparatus 3 – Reciprocating Cylinder (37 °C ± 0.5 °C)
Blend time is an important parameter to evaluate the mixing efficiency of mixing devices. [1] In order to make this definition valid, the tracer should be in the same physical phase (e.g. liquid) as the bulk material. Blend time can be determined either with experiments or numerical modeling, such as computational fluid dynamics (CFD).
According to the Biopharmaceutics Classification System (BCS) drug substances are classified to four classes upon their solubility and permeability: [1] Class I – high permeability, high solubility. Example: metoprolol, paracetamol [2] Those compounds are well absorbed and their absorption rate is usually higher than excretion.
In pharmaceutics, sink condition is a term mostly related to the dissolution testing procedure.. It means using a sheer volume of solvent, usually about 5 to 10 times greater than the volume present in the saturated solution of the targeted chemical (often the API, and sometimes the excipients) contained in the dosage form being tested.
A volumetric flask (measuring flask or graduated flask) is a piece of laboratory apparatus, a type of laboratory flask, calibrated to contain a precise volume at a certain temperature. Volumetric flasks are used for precise dilutions and preparation of standard solutions. These flasks are usually pear-shaped, with a flat bottom, and made of ...
The end of the holiday weekend added two fresh examples of a historic shift on Wall Street: More CEOs than ever are heading for the exits. Over the past 24 hours, the leaders of chipmaker Intel ...
From January 2008 to December 2012, if you bought shares in companies when Rudolph Harold Peter Markham joined the board, and sold them when he left, you would have a 4.5 percent return on your investment, compared to a -2.8 percent return from the S&P 500.
From January 2008 to December 2012, if you bought shares in companies when Gregory D. Brenneman joined the board, and sold them when he left, you would have a 128.0 percent return on your investment, compared to a -2.8 percent return from the S&P 500.