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The serotonin "chemical imbalance" theory of depression, proposed in the 1960s, [35] is not supported by the available scientific evidence. [ 35 ] [ 36 ] SSRIs alter the balance of serotonin inside and outside of neurons: their clinical antidepressant effect (which is robust in severe depression [ 37 ] ) is likely due to more complex changes in ...
The neurotrophic hypothesis of depression [1] proposes that major depressive disorder (MDD) is caused, at least partly, by impaired neurotrophic support.Neurotrophic factors (also known as neurotrophins) are a family of closely related proteins which regulate the survival, development, and function of neurons in both the central and peripheral nervous systems.
In neurophysiology, long-term depression (LTD) is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress.
In particular, the findings of specific neurological markers of individual preferences may have important implications for well-known economic models and paradigms. An example of this is the finding that an increase in computational capacity (likely related to increased gray matter volume) could lead to higher risk tolerance by loosening the ...
The Monoamine Theory of Depression and Anxiety, which states that the disruption of the activity of nitrogen containing neurotransmitters (i.e. serotonin, norepinephrine, and dopamine) is strongly correlated with the presence of depressive symptoms. [9]
Three alternative therapies emerged over the next 4 years: Lewinsohn's social learning theory, Patterson's anti-depression milieu, and Lazarus' behavioral deprivation. Social learning theory focused on identifying and avoiding behaviors that increased depressive thoughts. Anti-depression milieu encouraged catharsis to overcome depression.
The kindling hypothesis of depression posits that each period of depression in someone with major depressive disorder (MDD) causes neurological changes that predispose the person to future episodes. While the first episode of depression is often triggered by major life events, future episodes are less likely to be tied to circumstantial factors ...
While depression is a complex condition with many factors involved, it is commonly attributed to an imbalance of several key monoamine neurotransmitters, including serotonin, dopamine and norepinephrine. This monoamine hypothesis of depression is popular because of the simplicity of the explanation. [4]