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M. tuberculosis is able to reproduce inside the macrophage and will eventually kill the immune cell. The primary site of infection in the lungs, known as the Ghon focus, is generally located in either the upper part of the lower lobe, or the lower part of the upper lobe. [13] Tuberculosis of the lungs may also occur via infection from the blood ...
Viruses, however, use a completely different mechanism to cause disease. Upon entry into the host, they can do one of two things. Many times, viral pathogens enter the lytic cycle; this is when the virus inserts its DNA or RNA into the host cell, replicates, and eventually causes the cell to lyse, releasing more viruses into the environment.
Mycobacterium tuberculosis (M. tb), also known as Koch's bacillus, is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis. [1] [2] First discovered in 1882 by Robert Koch, M. tuberculosis has an unusual, waxy coating on its cell surface primarily due to the presence of mycolic acid.
An infectious disease agent can be transmitted in two ways: as horizontal disease agent transmission from one individual to another in the same generation (peers in the same age group) [3] by either direct contact (licking, touching, biting), or indirect contact through air – cough or sneeze (vectors or fomites that allow the transmission of the agent causing the disease without physical ...
2 weeks to months, or longer [15] 3 weeks to months, or longer Infectious mononucleosis (glandular fever) 28 days [16] 42 days Influenza: 1 day [17] 3 days Kuru disease: 10.3 years (mean) [18] 13.2 years Leprosy: 1 year [19] 20 or more years Marburg: 5 days [20] 10 days Measles: 9 days [21] 12 days MERS: 2 days [22] 14 days Mumps: 14 days [23 ...
Mycobacterium is a genus of over 190 species in the phylum Actinomycetota, assigned its own family, Mycobacteriaceae.This genus includes pathogens known to cause serious diseases in mammals, including tuberculosis (M. tuberculosis) and leprosy in humans.
The Wells-Riley model is a simple model of the airborne transmission of infectious diseases, [1] [2] developed by William F. Wells and Richard L. Riley for tuberculosis [3] and measles. [ 4 ] Wells-Riley can also be applied to other diseases transmitted in the air, such as COVID-19 .
In fact, death from tuberculosis was greater in diabetic patients. [9] Persons with HIV and latent tuberculosis have a 10% chance of developing active tuberculosis every year. "HIV infection is the greatest known risk factor for the progression of latent M. tuberculosis infection to active TB. In many African countries, 30–60% of all new TB ...