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Some research has suggested the half-life of clonidine is dose dependent and approximately doubles upon chronic dosing, [93] while other work contradicts this. [6] Following a 0.3 mg oral dose, a small study of five patients by Dollery et al. (1976) found half-lives ranging between 6.3 and 23.4 hours ( mean 12.7). [ 94 ]
Reproduction studies have been performed in female laboratory rabbits, mice, and rats at doses up to 1.3, 7, and 9 times the maximum daily human dose respectively and have revealed no evidence of impaired fertility or harm to the fetus due to maprotiline. There are, however, no adequate and well controlled studies in pregnant women.
Clonidine was initially developed as a treatment for high blood pressure. Low doses in evenings and/or afternoons are sometimes used in conjunction with stimulants to help with sleep and because clonidine sometimes helps moderate impulsive and oppositional behavior and may reduce tics. [95] It may be more useful for comorbid Tourette syndrome.
When you were 20, you could chug a double latte at 9 p.m., sleep through your alarm and wake up at noon. But now that you’re over 40, your relationship with sleep has gotten a lot more ...
There’s a difference between being totally over your day and sundowning. In addition to the symptoms listed above, sundowning can include verbal or even physical outbursts, Elhelou says.
Because these two functions frequently overlap, and because drugs in this class generally produce dose-dependent effects (ranging from anxiolysis to loss of consciousness) they are often referred to collectively as sedative-hypnotic drugs. [4] Sedatives can be used to produce an overly calming effect (alcohol being the most common sedating drug).
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