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Mechanism of self-amplifying mRNA (saRNA) used for antigen production. The ORF encoding the antigen can also be substituted with a protein for use in protein replacement therapy. This sequence encodes the protein of interest, used as an antigen in the case of vaccines or for protein replacement therapies. The gene of interest replaces the viral ...
To identify an saRNA that can activate a gene of interest, several saRNAs need to be designed within a 1- to 2-kbp promoter region by following a set of rules [3] [4] and tested in cultured cells. In some reports, saRNAs are designed in such a way to target non-coding transcripts that overlap the promoter sequence of a protein coding gene.
Sarnaism is a religious faith of the Indian subcontinent, predominantly followed by indigenous communities of Chota Nagpur Plateau region across states like Jharkhand, Odisha, West Bengal, Bihar, and Chhattisgarh.
Gritstone bio started also started a phase 1 trial of an saRNA COVID-19 vaccine in 2021, used as a booster vaccine, with interim results published in 2023. [105] The vaccine is designed to target both the spike protein of the SARS‑CoV‑2 virus, and viral proteins that may be less prone to genetic variation, to provide greater protection ...
This is a timeline of English history, comprising important legal and territorial changes and political events in England and its predecessor states. To read about the background to these events, see History of England .
Joseph Priestley's A New Chart of History, 1765 The bronze timeline "Fifteen meters of History" with background information board, Örebro, Sweden. A timeline is a list of events displayed in chronological order. [1] It is typically a graphic design showing a long bar labelled with dates paralleling it, and usually contemporaneous events.
Timeline of Cambridge; Timeline of Cheshire history; Timeline of Cornish history; Timeline of the COVID-19 pandemic in England (2021) Timeline of the COVID-19 pandemic in England (2022) Timeline of the COVID-19 pandemic in England (January–June 2020) Timeline of the COVID-19 pandemic in England (July–December 2020)
Sarna Burhi is described as being a goddess associated with spirits, rain, and plants. In the culture of the Munda and Kurukh peoples (both of which constitute part of the Adivasi peoples), [1] [2] Sarna Burhi is depicted as the guardian of Sarna, sacred groves of trees that serve as refuges for spirits displaced by human activity. [3]