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In osteoarthritis, there is a loss of articular hyaluronic acid activity, likely contributing to pain and stiffness associated with the condition. Hyaluronic acid injections are an FDA-approved treatment for osteoarthritis of the knee, and are sometimes also used for other joints. However, the merits of HA injections are still disputed.
Blume [1] Achyranthes bidentata Blume (English common name: ox knee, Chinese: 牛膝 niu xi[1]) is a species of flowering plant in the amaranth family, Amaranthaceae. It occurs in India, Nepal, Korea, China, and Japan. It is the source of the Chinese herbal medicine Huai'niuxi (Chinese: 怀牛膝; pinyin: Huái'niúxī). In Nepal its root juice ...
Osteoarthritis (OA) is a type of degenerative joint disease that results from breakdown of joint cartilage and underlying bone. [5][6] It is believed to be the fourth leading cause of disability in the world, affecting 1 in 7 adults in the United States alone. [7] The most common symptoms are joint pain and stiffness. [1]
Arthritis is a term often used to mean any disorder that affects joints. [2] Symptoms generally include joint pain and stiffness. [2] Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. [2][3] In some types of arthritis, other organs are also affected. [7]
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A disease-modifying osteoarthritis drug (DMOAD) is a disease-modifying drug that would inhibit or even reverse the progression of osteoarthritis. [1] Since the main hallmark of osteoarthritis is cartilage loss, a typical DMOAD would prevent the loss of cartilage and potentially regenerate it. Other DMOADs may attempt to help repair adjacent ...
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