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Fentanyl is a highly potent synthetic piperidine opioid primarily used as an analgesic. It is 20 to 40 times more potent than heroin and 100 times more potent than morphine; [ 9 ] its primary clinical utility is in pain management for cancer patients and those recovering from painful surgeries. [ 10 ][ 11 ] Fentanyl is also used as a sedative ...
The symptoms can often be divided into differing toxidromes. This can help one determine what class of drug or toxin is causing the difficulties. Symptoms of opioid overdoses include slow breathing, heart rate and pulse. [8] Opioid overdoses can also cause pinpoint pupils, and blue lips and nails due to low levels of oxygen in the blood.
Fenfluramine was marketed by American Home Products (later known as Wyeth) as Pondimin, but was shown to cause potentially fatal pulmonary hypertension and heart valve problems, which eventually led to its withdrawal in 1997 and legal damages of over $13 billion. [1] Phentermine was not shown to have harmful effects.
A two milligram dose of fentanyl powder (on pencil tip) is a lethal amount for most people. [ 3 ] The United States Centers for Disease Control and Prevention (CDC) has data on drug overdose death rates and totals. Around 1,106,900 US residents died from drug overdoses from 1968 to 2020. Around 932,400 died from 1999 through 2020.
While fentanyl is a strong drug, touching it or being close to it shouldn't cause accidental poisoning, Wakeman said. “You definitely cannot overdose or be harmed by simply being near fentanyl ...
It suppresses pain and sympathetic stimulation. Sympathetic stimulation can cause further injury to those with heart disease, aortic dissection, and aortic aneurysm. Fentanyl is ideal because of its rapid onset, lack of histamine release, high lipophilicity, and short duration of action. The dosage is between 1 and 3 μg/kg.
Contents. Malignant hyperthermia. Malignant hyperthermia (MH) is a type of severe reaction that occurs in response to particular medications used during general anesthesia, among those who are susceptible. [ 1 ] Symptoms include muscle rigidity, fever, and a fast heart rate. [ 1 ] Complications can include muscle breakdown and high blood ...
Many sources point to fentanyl as the leading cause of teen overdose death. According to a 2022 study in the Journal of the American Medical Association, between 2010 and 2021, the number of teenage deaths caused by black-market fentanyl and related synthetic substances increased more than twentyfold, from 38 to 884. [119]
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