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Follicular dendritic cells (FDC) are cells of the immune system found in primary and secondary lymph follicles (lymph nodes) of the B cell areas of the lymphoid tissue. [1][2][3] Unlike dendritic cells (DC), FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin. [4] Possible functions of FDC include ...
Anatomical terminology. [edit on Wikidata] A dendritic cell (DC) is an antigen-presenting cell (also known as an accessory cell) of the mammalian immune system. A DC's main function is to process antigen material and present it on the cell surface to the T cells of the immune system. They act as messengers between the innate and adaptive immune ...
Follicular dendritic cell sarcoma (FDCS) is an extremely rare neoplasm.While the existence of FDC tumors was predicted by Lennert in 1978, the tumor wasn't fully recognized as its own cancer until 1986 after characterization by Monda et al. [1] [2] It accounts for only 0.4% of soft tissue sarcomas, but has significant recurrent and metastatic potential and is considered an intermediate grade ...
The light zone consists of GC B cells and T follicular helper cells. [3] It is proximal to the lymph node and near the network of follicular dendritic cells. [3] The GC B cells in the light zone, known as centrocytes, are smaller, less abundant and divide less as compared to the GC B cells in the dark zone.
In immunology, a centroblast generally refers to an activated B cell that is enlarged (12–18 micrometer) and is rapidly proliferating in the germinal center of a lymphoid follicle. [1] They are specifically located in the dark zone of the germinal center. [2] Centroblasts form from naive B cells being exposed to follicular dendritic cell ...
[2] [4] MZ B cells shuttle between the blood-filled marginal zone for antigen collection and the follicle for antigen delivery to follicular dendritic cells. In mice, it has been shown that these cells shear flow via the LFA-1 integrin ligand ICAM-1 and adhere or migrate down the flow via the VLA-4 integrin ligand VCAM-1.
Patterns of CD21 (or CD23) expression by the follicular dendritic cells in follicular lymphoma. [13] Although CR2 is present on all mature B-cells and follicular dendritic cells (FDCs), this becomes readily apparent only when immunohistochemistry is performed on frozen sections. In more conventional paraffin-embedded tissue samples, only the ...
CD23 can also be demonstrated in germinal centre follicular dendritic cells using immunohistochemistry but is minimally expressed by benign germinal center B cells. In contrast to neoplastic mantle cells (which are negative for CD23), the resting cells of physiologic mantle zone express CD23.
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