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Mycosis fungoides, also known as Alibert-Bazin syndrome or granuloma fungoides, [1] is the most common form of cutaneous T-cell lymphoma. It generally affects the skin, but may progress internally over time.
The presentation depends if it is mycosis fungoides or Sézary syndrome, the most common, though not the only types. Among the symptoms for the aforementioned types are: enlarged lymph nodes, an enlarged liver and spleen, and non-specific dermatitis. [1]
Sézary disease and mycosis fungoides are cutaneous T-cell lymphomas having a primary manifestation in the skin. [5] The disease's origin is a peripheral CD4+ T-lymphocyte, [ 3 ] although rarer CD8+/CD4- cases have been observed. [ 3 ]
The premycotic phase is a phase of mycosis fungoides in which a patient has areas of red, scaly, itchy skin on areas of the body that are usually not exposed to sun. This is early-phase mycosis fungoides, but it is hard to diagnose the rash as mycosis fungoides during this phase. The premycotic phase may last from months to decades.
Cutaneous squamous-cell carcinoma (cSCC), also known as squamous-cell carcinoma of the skin or squamous-cell skin cancer, is one of the three principal types of skin cancer, alongside basal-cell carcinoma and melanoma. [10] cSCC typically presents as a hard lump with a scaly surface, though it may also present as an ulcer. [1]
Lymphoproliferative disorders are a set of disorders characterized by the abnormal proliferation of lymphocytes into a monoclonal lymphocytosis.The two major types of lymphocytes are B cells and T cells, which are derived from pluripotent hematopoietic stem cells in the bone marrow.
Melanoma has one of the higher survival rates among cancers, with over 86% of people in the UK and more than 90% in the United States surviving more than 5 years. [18] [19] Skin cancer is the most common form of cancer, globally accounting for at least 40% of cancer cases.
Fungal infection, also known as mycosis, is a disease caused by fungi. [ 5 ] [ 13 ] Different types are traditionally divided according to the part of the body affected; superficial, subcutaneous , and systemic.
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