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Apitherapy is a branch of alternative medicine that uses honey bee products, including honey, pollen, propolis, royal jelly and bee venom. There has been no scientific or clinical evidence for the efficacy or safety of apitherapy treatments. [1] [2] Bee venom can cause minor or major reactions, including allergic responses, anaphylaxis or death.
Bee venom is a complex mixture of proteins and smaller molecules. The main component is melittin, which amounts to 52% of venom peptides [2] One of the main allergens is phospholipase A 2, which amounts to 12% and is an enzyme that catalyzes the hydrolysis of phospholipids, causing degradation of cell membranes. [3]
Patients poisoned with bee venom can be treated with anti-inflammatory medication, antihistamines and oral prednisolone. [11] Apamin is an element in bee venom. A person can come into contact with apamin through bee venom, so the symptoms that are known are not caused by apamin directly, but by the venom as a whole.
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Melittin is the main compound in bee venom, accounting for the potential lethality of a bee sting, which causes an anaphylactic reaction in some people. [5] At the sites of multiple stings, localized pain, swelling, and skin redness occur, and if bees are swallowed, life-threatening swelling of the throat and respiratory passages may develop. [5]
While the detoxification foot pads seem to be popular among young populations in some regions, the effect of the pads remains unclear. "Removing heavy metals from the body" seems to be good for health; however, the human body needs certain amount of heavy metals such as zinc, iron, copper, etc. Excessive amounts of heavy metal can cause disease. [8]
An allergen is an otherwise harmless substance that triggers an allergic reaction in sensitive individuals by stimulating an immune response.. In technical terms, an allergen is an antigen that is capable of stimulating a type-I hypersensitivity reaction in atopic individuals through immunoglobulin E (IgE) responses. [1]