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A cancer vaccine, or oncovaccine, is a vaccine that either treats existing cancer or prevents development of cancer. [1] Vaccines that treat existing cancer are known as therapeutic cancer vaccines or tumor antigen vaccines. Some of the vaccines are "autologous", being prepared from samples taken from the patient, and are specific to that patient.
Matrix-M is a vaccine adjuvant, a substance that is added to various vaccines to stimulate the immune response. [1] [2] [3] It was patented in 2020 by Novavax [4] and is composed of nanoparticles from saponins extracted from Quillaja saponaria (soapbark) trees, cholesterol, and phospholipids.
The dendritic cell-based cancer vaccine is an innovation in therapeutic strategy for cancer patients. Dendritic cells (DCs) are antigen presenting cells for the induction of antigen specific T cell response. [1] DC-based immunotherapy is safe and can promote antitumor immune responses and prolonged survival of cancer patients. [2]
The results showed that a vaccine created based on a person's tumor cells can teach T-cells how to fight the melanoma with a 44% reduction in risk of recurrence of cancer and death.
The novel vaccine uses proteins unique to people’s tumors to train their immune systems to recognize cancer cells and then fight and hopefully kill the cells.
“Patients with Stage 3 or 4 kidney cancer are at high risk of recurrence,” Dr. Toni Choueiri, director of Dana-Farber’s Lank Center for Genitourinary Cancer, said in a news release about the ...
NeuVax has been tested as adjuvant treatment in nearly 200 breast cancer patients over a total of 5 years, and has shown to be safe and effective in Phase 2 trials. [6] As a result, two additional NeuVax trials registered or underway are: (1) a 700 patient Phase 3 trial for FDA approval - not yet recruiting [2] [needs update] and (2) a 300 patient Phase 2 trial studying the combination of ...
In vitro testing demonstrated that AOH1996 inhibited the growth and induced cell cycle arrest and apoptotic cell death in a wide variety of cancer cell lines, but had no effect on several normal, nonmalignant cell types. [6] [7] In mouse and dog animal models, there were no observed side effects or toxicity even at six times the effective dose. [3]