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  2. Patch clamp - Wikipedia

    en.wikipedia.org/wiki/Patch_clamp

    Classical patch clamp setup, with microscope, antivibration table, and micromanipulators. During a patch clamp recording, a hollow glass tube known as a micropipette or patch pipette filled with an electrolyte solution and a recording electrode connected to an amplifier is brought into contact with the membrane of an isolated cell.

  3. Electrophysiology - Wikipedia

    en.wikipedia.org/wiki/Electrophysiology

    The current clamp technique records the membrane potential by injecting current into a cell through the recording electrode. Unlike in the voltage clamp mode, where the membrane potential is held at a level determined by the experimenter, in "current clamp" mode the membrane potential is free to vary, and the amplifier records whatever voltage ...

  4. Automated patch clamp - Wikipedia

    en.wikipedia.org/wiki/Automated_patch_clamp

    A schematic of a patch clamp chip showing a gigaseal, whole cell recording configuration, and the ion channel and whole cell currents. Many types of systems have been developed for patch clamping cells in suspension cultures. One system uses a traditional pipette and cells in a droplet suspension culture to obtain patch clamp recordings (see ...

  5. Single-unit recording - Wikipedia

    en.wikipedia.org/wiki/Single-unit_recording

    In neuroscience, single-unit recordings (also, single-neuron recordings) provide a method of measuring the electro-physiological responses of a single neuron using a microelectrode system. When a neuron generates an action potential , the signal propagates down the neuron as a current which flows in and out of the cell through excitable ...

  6. Current clamp - Wikipedia

    en.wikipedia.org/wiki/Current_clamp

    A digital clamp meter A multimeter with built-in clamp. Pushing the large button at the bottom opens the lower jaw of the clamp, allowing the clamp to be placed around a conductor. An electrical meter with integral AC current clamp is known as a clamp meter, clamp-on ammeter, tong tester, or colloquially as an amp clamp.

  7. Electroanalytical methods - Wikipedia

    en.wikipedia.org/wiki/Electroanalytical_methods

    Chronoamperometry is the technique in which the current is measured, at a fixed potential, at different times since the start of polarisation. Chronoamperometry is typically carried out in unstirred solution and at the fixed electrode, i.e., under experimental conditions avoiding convection as the mass transfer to the electrode.

  8. Voltage clamp - Wikipedia

    en.wikipedia.org/wiki/Voltage_clamp

    Voltage and current errors: SEV-c circuitry does not actually measure the voltage of the cell being clamped (as does a two-electrode clamp). The patch-clamp amplifier is like a two-electrode clamp, except the voltage measuring and current passing circuits are connected (in the two-electrode clamp, they are connected through the cell). The ...

  9. Electromagnetic induction - Wikipedia

    en.wikipedia.org/wiki/Electromagnetic_induction

    A current clamp is a type of transformer with a split core which can be spread apart and clipped onto a wire or coil to either measure the current in it or, in reverse, to induce a voltage. Unlike conventional instruments the clamp does not make electrical contact with the conductor or require it to be disconnected during attachment of the clamp.