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PFOA can be absorbed from ingestion and can penetrate skin. [16] The acid headgroup of PFOA enables binding to proteins with fatty acid or hormone substrates such as serum albumin, liver fatty acid-binding protein, and the nuclear receptors PPARα [43] and possibly CAR. [126] In animals, PFOA is mainly present in the liver, blood, and kidneys. [16]
2016 The EPA "published a voluntary health advisory for PFOA and PFOS" which warned that "exposure to the chemicals at levels above 70 parts per trillion, total, could be dangerous." [71] 2016 The city of Lake Elmo, Minnesota, sued 3M a second time for polluting their drinking water with PFAS chemicals.
The Devil We Know is a 2018 investigative documentary film by director Stephanie Soechtig regarding allegations of health hazards from perfluorooctanoic acid (PFOA, also known as C8), a key ingredient used in manufacturing Teflon, and DuPont's potential responsibility.
The state added PFOA to its Proposition 65 list of chemicals that are known to cause reproductive toxicity in 2017 and to the list known to cause cancer in 2022. But it's one of only around a ...
Wyre Council said ICI, and subsequent site owner AGC Chemicals, were permitted to use PFOA from the 1950s to 2012. The substance was used in everyday items like non-stick pans and waterproof clothing.
Those surveyed had a range of PFOA levels from 0.2-22,412 μg/L, with a median exposure of 28.2 μg/L. [30] These levels were significantly higher than the levels detected in the general American population, which had a median exposure of 3.9μg/L. [30] Results from the study concluded that PFOA exposure was linked to pancreatic cancer and ...
PFOA and PFOS have been shown to significantly alter immune and inflammatory responses in human and animal species. In particular, IgA , IgE (in females only) and C-reactive protein have been shown to decrease whereas antinuclear antibodies increase as PFOA serum concentrations increase. [ 83 ]
Eye, skin, and respiratory irritation and in high volumes corrosion. Potentially disrupts thyroid hormones Perfluoro-octane sulfonate and Perfluorooctanoic acid (PFOA) Used in additives and coatings, non-stick cookware, waterproof clothing, cardboard packaging, wire casing, and resistant tubing