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In genetics and molecular biology, a corepressor is a molecule that represses the expression of genes. [1] In prokaryotes, corepressors are small molecules whereas in eukaryotes, corepressors are proteins. A corepressor does not directly bind to DNA, but instead indirectly regulates gene expression by binding to repressors.
As in other mammals, human thermoregulation is an important aspect of homeostasis. In thermoregulation, body heat is generated mostly in the deep organs, especially the liver, brain, and heart, and in contraction of skeletal muscles. [1] Humans have been able to adapt to a great diversity of climates, including hot humid and hot arid.
Corepressor proteins also bind to the surface of the ligand binding domain of nuclear receptors, but through a LXXXIXXX(I/L) motif of amino acids (where L = leucine, I = isoleucine and X = any amino acid). [7] In addition, compressors bind preferentially to the apo (ligand free) form of the nuclear receptor (or possibly antagonist bound receptor).
Repressible systems - A repressible system is on except in the presence of some molecule (called a corepressor) that suppresses gene expression. The molecule is said to "repress expression". The manner by which this happens is dependent on the control mechanisms as well as differences between prokaryotic and eukaryotic cells.
20185 Ensembl ENSG00000141027 ENSMUSG00000018501 UniProt O75376 Q60974 RefSeq (mRNA) NM_001190438 NM_001190440 NM_006311 NM_001252313 NM_011308 NM_177229 RefSeq (protein) NP_001177367 NP_001177369 NP_006302 n/a Location (UCSC) Chr 17: 16.03 – 16.22 Mb Chr 11: 62.21 – 62.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The nuclear receptor co-repressor 1 also known as thyroid ...
The ability of nuclear receptors to alternate between activation and repression in response to specific molecular cues, is now known to be attributable in large part to a diverse group of cellular factors, collectively termed coregulators and including coactivators and corepressors.
The nuclear receptor co-repressor 2 is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains.In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions.
LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.