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Hydrochlorothiazide, sold under the brand name Hydrodiuril among others, is a diuretic medication used to treat hypertension and swelling due to fluid build-up. [4] Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those with a high calcium level in the urine. [4]
They work primarily by expanding extracellular fluid and plasma volume, therefore increasing blood flow to the kidney, particularly the peritubular capillaries. This reduces medullary osmolality and thus impairs the concentration of urine in the loop of Henle (which usually uses the high osmotic and solute gradient to transport solutes and water).
Chronic administration of thiazides is associated with the increase of insulin resistance which can lead to hyperglycemia. [28] Thiazides cause loss of blood potassium, while conserving blood calcium. [citation needed] Thiazides can decrease placental perfusion and adversely affect the fetus, so should be avoided in pregnancy. [27] [29]
Studies on Long-Term Semaglutide Use. More studies are needed, but long-term semaglutide use appears to be safe. A 2022 study — funded by Novo Nordisk, the manufacturer of Ozempic and Wegovy ...
Certain beverages can complement the effects of weight loss medications, support hydration and provide essential nutrients, while others may lead to unwanted side effects or make it harder to lose ...
How to Start Losing Weight: 6 Tips. Many things about weight loss might be out of your control — like genetics or your set-point weight. But the good news is there are many things you can ...
Weight loss drugs have been developed since the early twentieth century, and many have been banned or withdrawn from the market due to adverse effects, including deaths; other drugs proved ineffective. Although many earlier drugs were stimulants such as amphetamines, in the early 2020s, GLP-1 receptor agonists became popular for weight loss.
Weight loss medications can definitely help make the road smoother, but they work best when combined with things like healthier lifestyle choices, a body-friendly diet and others.
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