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There is evidence that adults with schizophrenia demonstrate an increased incidence of autistic features compared to the general population, resulting in higher ADOS scores, though schizophrenia patients also experience positive symptoms of psychosis (e.g. hallucinations, delusions, formal thought disorders).
The K-SADS-PL is used to screen for affective and psychotic disorders as well as other disorders, including, but not limited to Major Depressive Disorder, Mania, Bipolar Disorders, Schizophrenia, Schizoaffective Disorder, Generalized Anxiety, Obsessive Compulsive Disorder, Attention Deficit Hyperactivity Disorder, Conduct Disorder, Anorexia Nervosa, Bulimia, and Post-Traumatic Stress Disorder. [4]
The autism diagnostic observation schedule (ADOS), is a companion instrument by the same core authors. It is a semi-structured set of observations and is conducted in an office setting as a series of activities involving the referred individual and a psychologist or other trained and licensed examiner.
The University of California, San Diego Performance-Based Skills Assessment (UPSA) was created by Dr. Thomas L. Patterson to provide a more reliable measure of every day functioning in patients with schizophrenia than the previously utilized methods such as self-report, clinician ratings or direct observation.
Furthermore, the presence of autism can make it harder to diagnose coexisting psychiatric disorders such as depression. [9] Diagnosing will be much harder in adults, since most people with ASD who reach adulthood undiagnosed, learn diverse (and often intense) masking techniques which make external diagnosis almost impossible.
A key secondary objective was to further evaluate the efficacy of TEV-'749 based on additional parameters in adult patients with schizophrenia. Assessment of the secondary objective that is still ongoing through Period 2 of the study is to evaluate the safety and tolerability of TEV-'749 in adult patients with schizophrenia.
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