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The genome and proteins of HIV (human immunodeficiency virus) have been the subject of extensive research since the discovery of the virus in 1983. [1] [2] "In the search for the causative agent, it was initially believed that the virus was a form of the Human T-cell leukemia virus (HTLV), which was known at the time to affect the human immune system and cause certain leukemias.
The HIV capsid consists of roughly 2000 copies of the p24 protein. The p24 structure is shown in two representations: cartoon (top) and isosurface (bottom) The p24 capsid protein is the most abundant HIV protein with each virus containing approximately 1,500 to 3,000 p24 molecules. [1]
The famous avant-garde director Rosa von Praunheim campaigned for AIDS education, safe sex and the rights of the infected with his art right from the start of the HIV epidemic. In the USA he was able to get a lot of attention with his films Silence = Death and Positive (1990), which deal particularly with the fight of American artists such as ...
A 3D representation that includes the retroviral psi packaging element. This is a solution RNA structure model of the HIV-1 dimerization initiation site in the kissing-loop dimer. [7] In HIV, the psi element is around 80–150 nucleotides in length, and located at the 5' end of the genome just upstream of the gag initiation codon. [8]
Visual AIDS is an art organization based in New York City. Started in 1988, it is one of the first initiatives to record the impact of the AIDS pandemic on the artistic community. Art institutions and AIDS-related communities co-developed projects like Day Without Art , Night Without Light , The Banner Project , Postcards from the Edge, [ 1 ...
On a special episode (first released on September 25, 2024) of The Excerpt podcast: This year, for just the seventh time since the start of the HIV pandemic, a person was cured of the virus. That ...
Since critical structure information is scarce on HIV integrase catalysis it is difficult to find the exact pharmacophore for its inhibition. Wang et al (2010) hoped that by studying the SAR and pharmacophore of a dual inhibitor scaffold, focusing both on integrase and reverse transcriptase (RT) it would be possible to observe anti-integrase ...
Preservation of this ratio has been shown to be essential to HIV-1 infectivity and structure, as even small changes in the efficiency of the frameshift lead to inhibition of viral propagation. [3] The dependence of the HIV-1 virus on this ribosomal frameshift signal has generated interest in the frameshift as a target for novel antiviral ...
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