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  2. p53 upregulated modulator of apoptosis - Wikipedia

    en.wikipedia.org/wiki/P53_upregulated_modulator...

    This increase in PUMA levels induces apoptosis through mitochondrial dysfunction. p53, and with it PUMA, is activated due to DNA damage caused by a variety of genotoxic agents. Other agents that induce p53 dependent apoptosis are neurotoxins, [16] [17] proteasome inhibitors, [18] microtubule poisons, [19] and transcription inhibitors. [20]

  3. p53 - Wikipedia

    en.wikipedia.org/wiki/P53

    p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates , where they prevent cancer formation. [ 5 ]

  4. Suicide gene - Wikipedia

    en.wikipedia.org/wiki/Suicide_gene

    In the field of genetics, a suicide gene is a gene that will cause a cell to kill itself through the process of apoptosis (programmed cell death). Activation of a suicide gene can cause death through a variety of pathways, but one important cellular "switch" to induce apoptosis is the p53 protein.

  5. Apoptosis - Wikipedia

    en.wikipedia.org/wiki/Apoptosis

    Part of this pathway includes alpha-interferon and beta-interferon, which induce transcription of the p53 gene, resulting in the increase of p53 protein level and enhancement of cancer cell-apoptosis. [85] p53 prevents the cell from replicating by stopping the cell cycle at G1, or interphase, to give the cell time to repair; however, it will ...

  6. Apoptosome - Wikipedia

    en.wikipedia.org/wiki/Apoptosome

    While apoptosis is required for natural body function, mutations of the apoptosome pathway cause catastrophic effects and changes in the body. Mutations of the cell pathway can either promote cell death or disallow cell death creating a huge amount of disease in the body.

  7. BH3 interacting-domain death agonist - Wikipedia

    en.wikipedia.org/wiki/BH3_interacting-domain...

    The expression of BID is upregulated by the tumor suppressor p53, and BID has been shown to be involved in p53-mediated apoptosis. [7] The p53 protein is a transcription factor that, when activated as part of the cell's response to stress, regulates many downstream target genes, including BID. However, p53 also has a transcription-independent ...

  8. Protein phosphorylation - Wikipedia

    en.wikipedia.org/wiki/Protein_phosphorylation

    One such example of the regulatory role that phosphorylation plays is the p53 tumor suppressor protein. The p53 protein is heavily regulated [28] and contains more than 18 different phosphorylation sites. Activation of p53 can lead to cell cycle arrest, which can be reversed under some circumstances, or apoptotic cell death. [29]

  9. Apoptosis-inducing factor - Wikipedia

    en.wikipedia.org/wiki/Apoptosis-inducing_factor

    Apoptosis inducing factor is involved in initiating a caspase-independent pathway of apoptosis (positive intrinsic regulator of apoptosis) by causing DNA fragmentation and chromatin condensation. Apoptosis inducing factor is a flavoprotein. [2] It also acts as an NADH oxidase. Another AIF function is to regulate the permeability of the ...