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  2. Rivaroxaban - Wikipedia

    en.wikipedia.org/wiki/Rivaroxaban

    Rivaroxaban bears a striking structural similarity to the antibiotic linezolid: both drugs share the same oxazolidinone-derived core structure. [39] Accordingly, rivaroxaban was studied for any possible antimicrobial effects and for the possibility of mitochondrial toxicity, which is a known complication of long-term linezolid use. [40]

  3. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    Antistasin, the first discovered naturally occurring direct Xa inhibitor Rivaroxaban, the first synthetic direct Xa inhibitor marketed as a drug Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood ...

  4. Deep vein thrombosis - Wikipedia

    en.wikipedia.org/wiki/Deep_vein_thrombosis

    Rivaroxaban is taken once daily, and apixaban is taken twice daily. [5] Warfarin, dabigatran, and edoxaban require the use of a parenteral anticoagulant to initiate oral anticoagulant therapy. [ 19 ] [ 125 ] When warfarin is initiated for VTE treatment, a 5-day minimum of a parenteral anticoagulant [ j ] together with warfarin is given, which ...

  5. Bayer's patent for blood thinner Xarelto invalid, UK court rules

    www.aol.com/news/bayers-patent-blood-thinner...

    Bayer's patent covering its best-selling blood thinner Xarelto is invalid, London's High Court ruled on Friday in a blow to the German drugmaker. The company's blockbuster Xarelto drug generated ...

  6. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Two hydrogen bonds are formed and serve an important role directing rivaroxaban into the S1 and S4 subsites. Due to these hydrogen bonds, rivaroxaban forms a L-shape and fits in the pockets. Chlorine substituent of the drug interacts with Tyr-228 in the S1 pocket which enables rivaroxaban to achieve good oral bioavailability and potency.

  7. Government shutdown odds are rising. Economic experts aren’t ...

    www.aol.com/finance/government-shutdown-odds...

    Varied economic effects The most expensive government shutdown in history led to about $3 billion permanently taken out of the US economy, according to the Congressional Budget Office. The reason ...

  8. Montana legislators reject bathroom ban for transgender ...

    www.aol.com/news/montana-legislators-reject...

    (Reuters) - Montana legislators on Tuesday rejected an attempt to ban a transgender member of the state House of Representatives from using the women's restroom at the state Capitol, with some ...

  9. Livedoid vasculopathy - Wikipedia

    en.wikipedia.org/wiki/Livedoid_vasculopathy

    Livedoid vasculopathy (LV) is an uncommon thrombotic dermal vasculopathy that is characterized by excruciating, recurrent ulcers on the lower limbs. [4] Livedo racemosa, along with painful ulceration in the distal regions of the lower extremities, is the characteristic clinical appearance.