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Organophosphate poisoning is poisoning due to organophosphates (OPs). [4] Organophosphates are used as insecticides , medications, and nerve agents . [ 4 ] Symptoms include increased saliva and tear production, diarrhea , vomiting, small pupils , sweating, muscle tremors, and confusion. [ 2 ]
As a result of cholinergic crisis, the muscles stop responding to the high synaptic levels of ACh, leading to flaccid paralysis, respiratory failure, and other signs and symptoms reminiscent of organophosphate poisoning. Other symptoms include increased sweating, salivation, bronchial secretions along with miosis (constricted pupils).
Cholinesterase reactivators are drugs that reverse the inhibition of cholinesterase by organophosphates or sulfonates. [1] They are used as antidote for treating organophosphate insecticide and nerve agent poisoning. [2] Organophosphates are used industrially in agricultural pesticides, and globally as agents of chemical warfare.
It can counteract the excessive cholinergic activity caused by dichlofenthion poisoning by blocking muscarinic receptors. Atropine administration helps alleviate symptoms such as excessive salivation, bronchoconstriction, and bradycardia. The goal of administering atropine is to prevent bradycardia, maintain blood pressure, clear lungs and dry ...
Aside from poisoning, a systemic infection may also lead to one. Classic toxidromes are presented below, which are variable [1] or obscured by co-ingestion of multiple drugs. [3] A common tool for assessing for the presence of toxidrome in the United Kingdom is the CRESS tool. [4] Toxidrome flowchart diagnosis
After arriving back home, the couple sought medical attention and were diagnosed with "likely organophosphate poisoning." Organophosphates are a type of human-made chemicals that are widely used ...
Sinus bradycardia due to a hypersensitive vagus nerve; Organophosphate based nerve agent poisoning, such as VX, sarin, tabun, and soman (atropine is favoured in conjunction with an oxime, usually pralidoxime) [6] [7]
regulatory program for implementing SMCRA and 30 C.F.R. §§ 780.21(b), 784.14(b) (2008), and their approved equivalents in the Pennsylvania state regulatory program for implementing SMCRA.