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Thus, the Haldane effect describes the ability of hemoglobin to carry increased amounts of carbon dioxide (CO 2) in the deoxygenated state as opposed to the oxygenated state. Vice versa, it is true that a high concentration of CO 2 facilitates dissociation of oxyhemoglobin, though this is the result of two distinct processes (Bohr effect and ...
The Haldane effect: most carbon dioxide is carried by the blood as bicarbonate, and deoxygenated hemoglobin promotes the production of bicarbonate. Increasing the amount of oxygen in the blood by administering supplemental oxygen reduces the amount of deoxygenated hemoglobin, and thus reduces the capacity of blood to carry carbon dioxide.
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John Scott Haldane CH FRS [1] (/ ˈ h ɔː l d eɪ n /; 2 May 1860 – 14/15 March 1936) was a Scottish physician physiologist and philosopher famous for intrepid self-experimentation which led to many important discoveries about the human body and the nature of gases. [2]
Upon the recommendation of Julian Huxley, the council appointed Haldane in March 1927, with the terms: "Mr. Haldane to visit the Institution fortnightly for a day and a night during the Cambridge terms, to put in two months also at Easter and long vacations in two continuous blocks and to be free in the Christmas vacation."
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