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The rapid plasma reagin test (RPR test or RPR titer) is a type of rapid diagnostic test that looks for non-specific antibodies in the blood of the patient that may indicate an infection by syphilis or related non-venereal treponematoses. It is one of several nontreponemal tests for syphilis (along with the Wassermann test and the VDRL test).
With nontreponemal tests, false-positive reactions can occur for a large number of reasons, the most common of which is other infections, both viral and bacterial. Additionally these tests may show false-negative when the patient's antibody titer is very high due to a hook effect (also called a prozone effect).
[1] [2] The primary stage classically presents with a single chancre (a firm, painless, non-itchy skin ulceration usually between 1 cm and 2 cm in diameter), though there may be multiple sores. [2] In secondary syphilis, a diffuse rash occurs, which frequently involves the palms of the hands and soles of the feet. [2] There may also be sores in ...
While case rates were rising in Spokane, there were 9.2 syphilis cases per 100,000 residents statewide in 2017, according to a 2021 report from the Washington State Department of Health. That ...
The Venereal Disease Research Laboratory test (VDRL) is a blood test for syphilis and related non-venereal treponematoses that was developed by the eponymous US laboratory. The VDRL test is used to screen for syphilis (it has high sensitivity ), whereas other, more specific tests are used to diagnose the disease.
Fig. 1: Microwells showing positive and negative TPHA test. The Treponema pallidum particle agglutination assay (also called TPPA test) is an indirect agglutination assay used for detection and titration of antibodies against the causative agent of syphilis, Treponema pallidum subspecies pallidum. It also detects other treponematoses. [citation ...
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