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The increased cell length can protect bacteria from protozoan predation and neutrophil phagocytosis by making ingestion of cells more difficult. [1] [3] [4] [5] Filamentation is also thought to protect bacteria from antibiotics, and is associated with other aspects of bacterial virulence such as biofilm formation. [6] [7]
Bacterial growth is proliferation of bacterium into two daughter cells, in a process called binary fission. Providing no mutation event occurs, the resulting daughter cells are genetically identical to the original cell. Hence, bacterial growth occurs. Both daughter cells from the division do not necessarily survive.
Bacterial cell division happens through binary fission or through budding. The divisome is a protein complex in bacteria that is responsible for cell division, constriction of inner and outer membranes during division, and remodeling of the peptidoglycan cell wall at the division site.
The choice of which formula to use depends on at which stage in the cell division that the mutations are expected to occur. [13] This method has since been improved on but these more accurate methods are complex. The Ma–Sandri–Sarkar maximum likelihood estimator is currently the best known estimator. [14]
DNA damage is the main indication for a cell to "restrict" and not enter the cell cycle. The decision to commit to a new round of cell division occurs when the cell activates cyclin-CDK-dependent transcription which promotes entry into S phase. This check point ensures the further process. [10]
Cell growth refers to an increase in the total mass of a cell, including both cytoplasmic, nuclear and organelle volume. [1] Cell growth occurs when the overall rate of cellular biosynthesis (production of biomolecules or anabolism) is greater than the overall rate of cellular degradation (the destruction of biomolecules via the proteasome, lysosome or autophagy, or catabolism).
The process of bacterial cell division is defined as binary fission, where a bacterium splits to produce two daughter cells. [4] This division occurs during cytokinesis, which in bacteria is made possible due to the divisome (a specific large protein complex) and FtsZ (the ancestor to tubulin for bacteria that drives cytokinesis itself). [4]
A plasmid partition system is a mechanism that ensures the stable inheritance of plasmids during bacterial cell division. Each plasmid has its independent replication system which controls the number of copies of the plasmid in a cell. The higher the copy number, the more likely the two daughter cells will contain the plasmid.