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Juvenile, in this context, refers to disease onset before 16 years of age, while idiopathic refers to a condition with no defined cause, and arthritis is inflammation within the joint. [ 4 ] JIA is an autoimmune, noninfective, inflammatory joint disease, the cause of which remains poorly understood.
Specific genetic markers, such as HLA (human leukocyte antigen) genes, have been associated with an increased risk of developing the disease. The HLA-DRB1 gene, for example, is linked to rheumatoid arthritis in adults and similar associations have been observed in juvenile arthritis, suggesting a genetic overlap between these conditions.
According to estimates, juvenile idiopathic arthritis (JIA) affects 1 to 4 out of every 1000 children, making it the most prevalent rheumatic illness in children. [ 34 ] [ 35 ] With incidence rates ranging from 0.4 to 0.8 children per 100,000 children, sJIA accounts for 10% to 20% of JIA cases.
[10] [5] [6] The most common forms are osteoarthritis (degenerative joint disease) and rheumatoid arthritis. [7] Osteoarthritis usually occurs with age and affects the fingers, knees, and hips. [7] [11] Rheumatoid arthritis is an autoimmune disorder that often affects the hands and feet. [7] Other types include gout, lupus, fibromyalgia, and ...
How are you holding up? Are you over it? I'm over it. I'm fine. At least, at times I think that. It's obviously not what I wanted but that's life. I'm not going to lie. It been an adjustment, but ...
Tiger Woods remains in recovery mode and feels physically unprepared to compete on the golf course after undergoing another back surgery in September. Woods, a bystander in the Hero World ...
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. [1] It typically results in warm, swollen, and painful joints. [1] Pain and stiffness often worsen following rest. [1] Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. [1]
Image source: Getty Images. If you feel like driving is more expensive than ever, you're not alone. Car ownership costs -- including auto insurance -- have increased dramatically in recent years.