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Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa).
The mammalian target of rapamycin (mTOR), [5] also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. [6] [7] [8] mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein ...
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...
With another approach, researchers at Columbia University have been investigating the use of the immunosuppressant drug rapamycin, which is typically used to prevent organ transplant rejection, in ...
Rapamycin was the first known inhibitor of mTORC1, considering that mTORC1 was discovered as being the target of rapamycin. [83] Rapamycin will bind to cytosolic FKBP12 and act as a scaffold molecule, allowing this protein to dock on the FRB regulatory region (FKBP12-Rapamycin Binding region/domain) on mTORC1. [84]
Rapamycin-insensitive companion of mTOR , mammalian stress-activated protein kinase interacting protein 1 , and protein observed with rictor 1 and 2 (Protor1/2) can only be found in mTORC2. [2] [3] Rictor has been shown to be the scaffold protein for substrate binding to mTORC2. [4]
Besides launching membership packages, Kuo is interested in setting up an online destination for longevity medications like metformin and rapamycin, a controversial immunosuppressant the death ...
Sirolimus (also known as rapamycin) is an antifungal and immunosuppressant that has been isolated from S. hygroscopicus from soil samples from Easter Island. [4] Ascomycin is another immunosuppressant produced by some strains of S. hygroscopicus; it has a similar structure to sirolimus and can be used to treat autoimmune diseases and skin diseases and can help prevent rejection after an organ ...