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GM2A is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation. This protein binds molecules of ganglioside GM2, extracts them from membranes, and presents them to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
APC activity requires association with activator subunits (Cdc20 or Cdh1) that contribute to substrate binding. Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome.
A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. [1] Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur.
This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. [7] BAFF is a 285-amino acid long peptide glycoprotein which undergoes glycosylation at residue 124.
Hexokinase-I (HK-I) is an enzyme activator because it draws glucose into the glycolysis pathway. Its function is to phosphorylate glucose releasing glucose-6-phosphate (G6P) as the product. HK-I not only signals the activation of glucose into glycolysis but also maintains a low glucose concentration to facilitate glucose diffusion into the cell.
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A recent study from Stanford University that involved lacing raw milk with flu virus and testing it on cells in a Petri dish found that the virus could still infect cells for up to five days after ...
How to Have More Energy: 7 Tips. This article was reviewed by Craig Primack, MD, FACP, FAAP, FOMA. Life can get incredibly busy, and keeping up often hinges on having enough energy.