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Sjögren syndrome (an early symptom in some patients) [8] Medications that can cause overproduction of saliva include: [4] aripiprazole; clozapine; pilocarpine; ketamine; potassium chlorate; risperidone; pyridostigmine; Substances that can cause hypersalivation include: [4] mercury; copper; organophosphates (insecticide) arsenic; nicotine; thallium
Drooling or sialorrhea can occur during sleep. It is often the result of open-mouth posture from CNS depressants intake or sleeping on one's side. Sometimes while sleeping, saliva does not build up at the back of the throat and does not trigger the normal swallow reflex, leading to the condition.
Cases of the syndrome were first observed in three elderly female patients with presenile dementia. Each of these women were undergoing treatment with the antipsychotic drug methylperone, haloperidol or a combination of the two. The use of neuroleptic drugs caused the patients to exhibit a lateral flexion along with a rotation of the trunk.
This is a list of drugs and substances that are known or suspected to cause Stevens–Johnson syndrome This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources .
A medication which is known to cause xerostomia may be termed xerogenic. [3] Over 400 medications are associated with xerostomia. [8] Although drug induced xerostomia is commonly reversible, the conditions for which these medications are prescribed are frequently chronic. [8]
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Xerostomia itself has many possible causes, but commonly the cause may be side effects of medications, or conditions such as Sjögren's syndrome. Conversely, conditions which cause drooling or sialorrhoea (excessive salivation) can cause angular cheilitis by creating a constant wet environment in the corners of the mouth.
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