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There is also evidence that antidepressant discontinuation syndrome may be related to the biological half-life of both SSRIs [24] and antidepressants in general. Antidepressants with a lower half-life, such as paroxetine , duloxetine , and venlafaxine , have been implicated in higher incidences of withdrawal symptoms and more severe withdrawal ...
Typically, brain zaps are associated with antidepressant discontinuation syndrome (ADS), which impacts an estimated 20 percent of people who abruptly stop or reduce their use of medication.
SSRIs can also cause a dangerous reaction called serotonin syndrome when used with other serotonin-affecting drugs. Withdrawal symptoms. Abruptly stopping medications like SSRIs or other ...
The analysis also found that severe discontinuation symptoms, which might cause patients to drop out of a study or resume taking antidepressants, occurred in about 3% — or one in 35 — of those ...
Where risks or harms is the reason for withdrawal, this will usually have been prompted by unexpected adverse effects that were not detected during Phase III clinical trials, i.e. they were only made apparent from postmarketing surveillance data collected from the wider community over longer periods of time.
If the symptoms are mild, treatment may only consist of discontinuation of the offending medication or medications, offering supportive measures, giving benzodiazepines for myoclonus, and waiting for the symptoms to resolve. Moderate cases should have all thermal and cardiorespiratory abnormalities corrected and can benefit from serotonin ...
Common side effects of antidepressant switching or discontinuation include: Returning symptoms of depression. Suicidal thoughts. Serotonin syndrome. Irritability. Flu-like symptoms. Dizziness.
SSRI drugs, which have an important use as antidepressants, engender a discontinuation syndrome that manifests with physical side effects; e.g., there have been case reports of a discontinuation syndrome with venlafaxine (Effexor). [24]