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Triple-negative is sometimes used as a surrogate term for basal-like. [2] Triple-negative breast cancer comprises 15–20% of all breast cancer cases [3] and affects more young women or women with a mutation in the BRCA1 gene than other breast cancers. [4] Triple-negative breast cancers comprise a very heterogeneous group of cancers.
One of these — triple-negative breast cancer (TNBC) — is an aggressive type of breast cancer that tends to grow and spread rapidly, and has a worse prognosis than other breast cancers.
Conversely, triple negative cancer (i.e. no positive receptors), lacking targeted treatments, now has a comparatively poor prognosis. [42] [43] Androgen receptor is expressed in 80-90% of ER+ breast cancers and 40% of "triple negative" breast cancers. Activation of androgen receptors appears to suppress breast cancer growth in ER+ cancer while ...
Triple negative breast cancer, in particular, has a worse prognosis and can be difficult to treat. There are few targeted therapies like there are for estrogen positive breast cancers, she says.
This is an accepted version of this page This is the latest accepted revision, reviewed on 21 December 2024. Cancer that originates in mammary glands Medical condition Breast cancer An illustration of breast cancer Specialty Oncology Symptoms A lump in a breast, a change in breast shape, dimpling of the skin, fluid from the nipple, a newly inverted nipple, a red scaly patch of skin on the ...
Deaths from breast cancer are declining overall, but disparities among women of color persist. ... Black women face higher risks of triple-negative breast cancers and have the lowest survival ...
HER/neu-negative PACB is one of the triple-negative breast cancers (TNBCs). TNBCs are a group of estrogen receptor-, androgen receptor-, and HER2/neu-negative tumors that account for 10%-15% of all breast cancers and are particularly aggressive cancers that generally have a poorer prognosis than other breast cancer subtypes. [18]
As more young people are diagnosed with breast cancer, they worry about returning stage 4, metastatic breast cancer. ... That led to a diagnosis of Stage 3 triple-positive, inflammatory breast ...
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