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Choroideremia (/ k ɒ ˌ r ɔɪ d ɪ ˈ r iː m i ə /; CHM) is a rare, X-linked recessive form of hereditary retinal degeneration that affects roughly 1 in 50,000 males. The disease causes a gradual loss of vision, starting with childhood night blindness, followed by peripheral vision loss and progressing to loss of central vision later in life.
Without thyroidectomy, almost all patients with MEN2B develop medullary thyroid cancer, in a more aggressive form than MEN 2A. [13] [19] The ideal age for surgery is 4 years old or younger, since cancer may metastasize before age 10. [14] Pheochromocytoma - a hormone secreting tumor of the adrenal glands - is also present in 50% of cases. [14]
Choroideremia is caused by a loss-of-function mutation in the CHM gene which codes for Rab escort protein (REP-1). REP-1 and REP-2 (a REP-1 like protein) both help with the prenylation and transport of Rab proteins. [6] Rab27 has been found to preferentially depend on REP-1 for prenylation, which could be the underlying cause of choroideremia. [7]
At least three cancers with high mortality risk impact Black men disproportionately. Cancer deaths among men could potentially be on […] Cancer deaths in men are expected to rise 93% by 2050.
Cancer-related fatigue is a symptom of fatigue that is experienced by nearly all cancer patients. [1] Among patients receiving cancer treatment other than surgery, it is essentially universal. Fatigue is a normal and expected side effect of most forms of chemotherapy, radiation therapy, and biotherapy. [2]
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Multiple endocrine neoplasia type 2 (also known as "Pheochromocytoma (codons 630 and 634) and amyloid producing medullary thyroid carcinoma", [1] "PTC syndrome," [1] and "Sipple syndrome" [1]) is a group of medical disorders associated with tumors of the endocrine system.
Prostate cancer is second for men, and breast cancer is second for women. Colorectal cancer is third, overall, for both sexes. The diagnosis of late-stage colorectal cancer was a shock to Sierra ...