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These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
Individual dogs of any breed can have a profound reaction characterized by hypotension, especially if there is an underlying heart problem. In giant-breed dogs and sighthounds, the sedative effects of acepromazine may last for 12–24 hours, which is much longer than the usual 3–4 hours. [16] [20]
Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. [1] It is uncommonly used in humans as an antipsychotic drug.
Serious side effects are valid for all atypical antipsychotics and may include the potentially permanent movement disorder tardive dyskinesia, as well as neuroleptic malignant syndrome, an increased risk of suicide, angioedema, and high blood sugar levels, [10] although lurasidone is less likely to cause high blood sugar levels in most patients ...
Side effects of azapirones may include dizziness, headaches, restlessness, nausea, and diarrhea. [4] [22]Azapirones have more tolerable adverse effects than many other available anxiolytics, such as benzodiazepines or SSRIs.
The greater risk of serious side effects with antipsychotics is why, e.g., quetiapine was denied approval as monotherapy for major depressive disorder or generalized anxiety disorder, and instead was only approved as an adjunctive treatment in combination with traditional antidepressants. [66]
Some adverse effects can be treated symptomatically by using adjunct medications such as anticholinergics (antimuscarinics). Some rebound or withdrawal adverse effects, such as the possibility of a sudden or severe emergence or re-emergence of psychosis in antipsychotic withdrawal, may appear when the drugs are discontinued, or discontinued too ...
Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia). Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions.
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